Insights into platinum-induced peripheral neuropathy–current perspective
Andrijana Lazi?1
Jelena Popovi?2
Tatjana Paunesku2
Gayle E.Woloschak2
Milena Stevanovi?3
1.Institute of Molecular Genetics and Genetic Engineering,University of Belgrade,Belgrade,Serbia2.Feinberg School of Medicine,Department of Radiation Oncology,Northwestern University,Chicago,IL,USA3.Institute of Molecular Genetics and Genetic Engineering,University of Belgrade,Belgrade,Serbia;Faculty of Biology,University of Belgrade,Belgrade,Serbia;Serbian Academy of Sciences and Arts,Belgrade,Serbia
摘要：Cancer is a global health problem that is often successfully addressed by therapy, with cancer survivors increasing in numbers and living longer world around. Although new cancer treatment options are contin-uously explored, platinum based chemotherapy agents remain in use due to their effciency and availability. Unfortunately, all cancer therapies affect normal tissues as well as cancer, and more than 40 specific side effects of platinum based drugs documented so far decrease the quality of life of cancer survivors. Chemo-therapy-induced peripheral neuropathy is a frequent side effects of platinum-based chemotherapy agents. This cluster of complications is often so debilitating that patients occasionally have to discontinue the ther-apy. Sensory neurons of dorsal root ganglia are at the core of chemotherapy-induced peripheral neuropathy symptoms. In these postmitotic cells, DNA damage caused by platinum chemotherapy interferes with normal functioning. Accumulation of DNA-platinum adducts correlates with neurotoxic severity and de-velopment of sensation of pain. While biochemistry of DNA-platinum adducts is the same in all cell types, molecular mechanisms affected by DNA-platinum adducts are different in cancer cells and non-dividing cells. This review aims to raise awareness about platinum associated chemotherapy-induced peripheral neuropathy as a medical problem that has remained unexplained for decades. We emphasize the complex-ity of this condition both from clinical and mechanistical point of view and focus on recent findings about chemotherapy-induced peripheral neuropathy in in vitro and in vivo model systems. Finally, we summarize current perspectives about clinical approaches for chemotherapy-induced peripheral neuropathy treatment.
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论文发表日期：2020-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1623-1630 )
英文信息