Intravitreal stem cell paracrine properties as a potential neuroprotective therapy for retinal photoreceptor neurodegenerative diseases
Kevin Puertas-Neyra1
Ricardo Usategui-Martín1
Rosa M.Coco2
Ivan Fernandez-Bueno2
1.Instituto Universitario de of talmobiología Aplicada,Universidad de Valladolid,Valladolid,Spain2.Instituto Universitario de of talmobiología Aplicada,Universidad de Valladolid,Valladolid,Spain;Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León,Valladolid,Spain;Red Temática de Investigación Cooperativa en Salud,of tared,Instituto de Salud Carlos III,Valladolid,Spain
摘要：Retinal degenerations are the leading causes of irreversible visual loss worldwide. Many pathologies in-cluded under this umbrella involve progressive degeneration and ultimate loss of the photoreceptor cells, with age-related macular degeneration and inherited and ischemic retinal diseases the most relevant. These diseases greatly impact patients' daily lives, with accompanying marked social and economic consequences. However, the currently available treatments only delay the onset or slow progression of visual impairment, and there are no cures for these photoreceptor diseases. Therefore, new therapeutic strategies are being in-vestigated, such as gene therapy, optogenetics, cell replacement, or cell-based neuroprotection. Specifically, stem cells can secrete neurotrophic, immunomodulatory, and anti-angiogenic factors that potentially pro-tect and preserve retinal cells from neurodegeneration. Further, neuroprotection can be used in different types of retinal degenerative diseases and at different disease stages, unlike other potential therapies. This review summarizes stem cell-based paracrine neuroprotective strategies for photoreceptor degeneration, which are under study in clinical trials, and the latest preclinical studies. Effective retinal neuroprotection could be the next frontier in photoreceptor diseases, and the development of novel neuroprotective strate-gies will address the unmet therapeutic needs.
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论文发表日期：2020-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1631-1638 )
英文信息