Comparing silicone oil-induced ocular hypertension with other inducible glaucoma models in mice
Jie Zhang
Yang Hu
1.Department of Ophthalmology,Stanford University School of Medicine,Palo Alto,CA,USA2.Department of Ophthalmology,Stanford University School of Medicine,Palo Alto,CA,USA
摘要：Glaucoma, "a silent thief of sight" and the leading cause of irreversible blindness, is characterized by retinal ganglion cell (RGC) death and optic nerve degeneration. Elevation of intraocular pressure (IOP), also called ocular hypertension, is the most recognized risk factor for glau-coma (Jonas et al., 2017). Current therapies only target reduction of IOP, but irreversible RGC death continues even after IOP is normalized (Wormald et al., 2020), indicating the critical clinical need to prevent degeneration and/or replace lost RGCs. Deciphering the key molecular mechanisms of glaucomatous degeneration and identifying or testing novel therapeutic targets for neuroprotection and regeneration, requires reliable, reproducible, and reversible ocular hypertension/glaucoma models in experimental animals. Due to the similarity of its anatomical structure and aqueous humor dynamics to those of the human eye, its strong reproductive ability, genetic plasticity, well developed transgenic techniques, and low price, the mouse has been used extensively to mod-el glaucoma. While genetic mouse models are valuable to understand the roles of a specific gene in IOP elevation and/or glaucomatous neu-rodegeneration, the pathologic effects of a mutation may not manifest for months or even years (Libby et al., 2005; Chi et al., 2010). Inducible ocular hypertension that develops more quickly and is more severe is preferable for testing experimental manipulations and studying neuro-degeneration mechanism associated with IOP elevation.
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论文发表日期：2020-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1652-1653 )