Understanding metabolic flexibility: a potential key to unlocking metabolic therapies in amyotrophic lateral sclerosis?
Scott P.Allen
Sheffeld Institute for Translational Neuroscience,University of Sheffeld,Sheffeld,UK
摘要：The role of metabolism in amyotrophic lateral sclerosis (ALS): ALS, is a predominantly sporadic, neurological disorder resulting in degeneration of both upper and lower motor neurons, resulting in the progressive failure of the neuromuscular system. The lifetime risk factor for developing ALS sits between 1 in 300 and 1 in 400. However, due to the speed of the disease course (2–3 years post-diagnosis) and the lack of effective therapies, ALS is still classified as a rare disease. It is well established that ALS affects energy generation not only in the central nervous system (CNS) but in the periph-ery (Vandoorne et al., 2018). However, the question of whether metabolic dysfunction is the primary cause of ALS or a secondary effect has been the topic of discussion in the field for many years.
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论文发表日期：2020-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1654-1655 )