Offspring of rats with cerebral hypoxia-ischemia manifest cognitive dysfunction in learning and memory abilities
Lu-Lu Xue1
Fang Wang2
Rui-Ze Niu3
Ya-Xin Tan4
Jia Liu3
Yuan Jin4
Zheng Ma4
Zi-Bin Zhang5
Ya Jiang3
Li Chen5
Qing-Jie Xia5
Jun-Jie Chen6
Ting-Hua Wang7
Liu-Lin Xiong8
1.Department of Anesthesiology,Affliated Hospital of Zunyi Medical University,Zunyi,Guizhou Province,China;Institute of Neuroscience,Kunming Medical University,Kunming,Yunnan Province,China2.Department of Science and Technology,Kunming Medical University,Kunming,Yunnan Province,China3.Department of Laboratory Zoology,Kunming Medical University,Kunming,Yunnan Province,China4.Institute of Neuroscience,Kunming Medical University,Kunming,Yunnan Province,China5.Institute of Neurological Disease,Department of Anesthesiology,Translational Neuroscience Center,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China6.Southwest Medical University,Luzhou,Sichuan Province,China7.Institute of Neuroscience,Kunming Medical University,Kunming,Yunnan Province,China;Institute of Neurological Disease,Department of Anesthesiology,Translational Neuroscience Center,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China8.Department of Anesthesiology,Affliated Hospital of Zunyi Medical University,Zunyi,Guizhou Province,China;School of Pharmacy and Medical Sciences,Division of Health Sciences,University of South Australia,Adelaide,Australia
摘要：Neonatal hypoxic-ischemic encephalopathy is a serious neurological disease, often resulting in long-term neurodevelopmental disorders among surviving children. However, whether these neurodevelopmental issues can be passed to offspring remains unclear. The right common carotid artery of 7-day-old parental-generation rats was subjected to permanent ligation using a vessel electrocoagulator. Neo-natal hypoxic-ischemic rat models were established by subjecting the rats to 8％ O2–92％ N2 for 2 hours. The results showed that 24 hours after hypoxia and ischemia, pathological damage, cerebral atrophy, liquefaction, and impairment were found, and Zea-Longa scores were significantly increased. The parental-generation rats were propagated at 3 months old, and offspring were obtained. No changes in the over-all brain structures of these offspring rats were identified by magnetic resonance imaging. However, the escape latency was longer and the number of platform crossings was reduced among these offspring compared with normal rats. These results indicated that the offspring of hypoxic-ischemic encephalopathy model rats displayed cognitive impairments in learning and memory. This study was approved by the Animal Care & Welfare Committee of Kunming Medical University, China in 2018 (approval No. kmmu2019072).
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论文发表日期：2020-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1662-1670 )
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