Green tea catechins inhibit microglial activation which prevents the development of neurological disorders
Tahereh Farkhondeh1
Ali Mohammad Pourbagher-Shahri2
Milad Ashrafizadeh3
Silvia Llorens Folgado4
Ali Rajabpour-Sanati2
Mohammad Reza Khazdair1
Saeed Samarghandian5
1.Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran2.Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran3.Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran4.Department of Medical Sciences, Faculty of Medicine of Albacete, Centro Regional de Investigaciones Biomédicas (CRIB), University of Castilla-La Mancha, Albacete, Spain5.Healthy Ageing Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran;Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran
摘要：The over-activated microglial cells induce neuroinflammation which has the main role in neurological disorders. The over-activated microglia can disturb neuronal function by releasing inflammatory media-tors leading to neuronal dysfunctions and death. Thus, inhibition of over-activated microglia may be an effective therapeutic approach for modulating neuroinflammation. Experimental?studies have indicated ?an-ti-neuroinflammatory?effects of?flavonoids such as green tea catechins. The current research was aimed to review the effect of green tea catechins in inhibiting microglial cells, inflammatory cascades, and subse-quent neurological diseases.
机标关键词：developmentwhichgreenactivationcatechinsdisordersinhibitmicroglial
论文发表日期：2020-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1792-1799 )
英文信息