Progesterone for the treatment of central nervous system disorders:the many signaling roads for a single molecule
Susana Laura González
Universidad de Buenos Aires, Facultad de Medicina, Departamento de Bioquímica Humana, Buenos Aires
摘要：Central nervous system (CNS) injuries and neurodegenerative diseases show a broad spectrum of common pathophysiological processes, including oxida-tive stress, neuroinflammation, excitotoxicity, demyelination and neurotrans-mission dysfunctions. Over the past decades, valuable experimental investi-gations have helped to clarify the role and timing of these multiple molecular and cellular mechanisms in each of these particular disorders, which usually overlap and critically contribute to long-term disability. However, up to now, no definite cures or effective disease-modifying therapies are available for any of these conditions. This has led to an active search of novel therapeutic ap-proaches, including the repositioning of existing drugs for new indications, as a valid approach to promptly move candidate molecules to clinical trials.
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论文发表日期：2020-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1846-1848 )