Limited therapeutic potential of astrocyte elevated gene-1 transduction in an animal model of Parkinson's disease
Eunju Leem1
Sang Ryong Kim2
1.School of Life Sciences, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea2.School of Life Sciences, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea;Brain Science and Engineering Institute, Kyungpook National University, Daegu, Korea
摘要：Biological roles of astrocyte elevated gene-1 (AEG-1): AEG-1, also known as metadherin, was originally identified as a human im-munodeficiency virus-1- and tumor necrosis factor-alpha-inducible gene in human fetal astrocytes. The increase in AEG-1 expression is a well-established and important oncogenic event in various types of human cancer, and its upregulation triggers evasion of cellular apoptosis, metastasis, and invasion in cancer (Emdad at al., 2016;Dhiman et al., 2019). AEG-1 can promote tumor progression via multiple phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathways, contributing to an invasive phenotype and angiogenesis (Emdad at al., 2016; Dhiman et al., 2019). In addition, there is evi-dence for a functional link between AEG-1 and pro-survival mech-anisms in various cancers (Dhiman et al., 2019), suggesting that AEG-1 is a key molecule for oncogenic events in cancer.
机标关键词：parkinsonlimitedmodelanimalastrocytediseaseelevatedgene-1
论文发表日期：2020-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1850-1852 )