When the left side knows something happened to the right – sensing injury in neurons contralateral and remote to injury
Valerie M.K. Verge1
Jovan C.D. Hasmatali2
Vikram Misra3
1.Department of Anatomy, Physiology and Pharmacology, Cameco MS Neuroscience Research Center, University of Saskatchewan, Saskatoon, Saskatchewan, Canada2.Department of Anatomy, Physiology and Pharmacology, Cameco MS Neuroscience Research Center, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;Department of Critical Care Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada;Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada3.Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
摘要：How sensory neurons encode axonal injury signals has been a longstand-ing area of neurological research. Insights into the cellular and transcrip-tional changes in the injured neurons have driven many new therapeutic strategies to improve repair. In contrast, less focus has been centered on the systemic or transneuronal changes that may arise from these injuries and how they may impact or factor into the alterations in gene expres-sion, physiology and neuropathology, such as mirror image pain, arising in regions either directly contralateral or those remote to the injury site. Research in this area is clinically relevant. In patients with chronic uni-lateral pain due to multiple pathologies, many of which involve nerve trauma, there is a very high incidence of bilateral sensory abnormalities reported with 33–50% of patients with mechanical abnormalities report-ing contralateral sensory abnormalities (Konopka et al., 2012). This has implications when evaluating sensory abnormalities or pain states in pa-tients, as the contralateral side is often used as the non-affected control. Further, the bilateral nature of these sensory abnormalities, albeit usually less severe on the contralateral side, support that a systemic or central nervous system component is involved in this aspect of the pathology. It highlights the need to better understand the mechanisms underlying these bilateral responses as this will likely impact therapeutic treatments for these patients.
机标关键词：somethingrightwhensidecontralateralhappenedinjuryknows
论文发表日期：2020-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1854-1856 )