Dopamine: an immune transmitter
Sarah Thomas Broome1
Krystal Louangaphay1
Kevin A. Keay2
Gian Marco Leggio3
Giuseppe Musumeci4
Alessandro Castorina5
1.Laboratory of Cellular and Molecular Neuroscience(LCMN),School of Life Science,Faculty of Science,University of Technology Sydney,Sydney,Australia2.Laboratory of Neural Structure and Function(LNSF),School of Medical Sciences,(Anatomy and Histology),Faculty of Medicine and Health,University of Sydney,Sydney,Australia3.Section of Pharmacology,Department of Biomedical and Biotechnological Sciences,University of Catania,Catania,Italy4.Section of Human Anatomy and Histology,Department of Biomedical and Biotechnological Sciences,University of Catania,Catania,Italy5.Laboratory of Cellular and Molecular Neuroscience(LCMN),School of Life Science,Faculty of Science,University of Technology Sydney,Sydney,Australia;Laboratory of Neural Structure and Function(LNSF),School of Medical Sciences,(Anatomy and Histology),Faculty of Medicine and Health,University of Sydney,Sydney,Australia
摘要：The dopaminergic system controls several vital central nervous system functions, including the control of movement, reward behaviors and cognition. Alterations of dopaminergic signaling are involved in the pathogenesis of neurodegenerative and psychiatric disorders, in particular Parkinson's disease, which are associated with a subtle and chronic inflammatory response. A substantial body of evidence has demonstrated the non-neuronal expression of dopamine, its receptors and of the machinery that governs synthesis, secretion and storage of dopamine across several immune cell types. This review aims to sum-marize current knowledge on the role and expression of dopamine in immune cells. One of the goals is to decipher the complex mechanisms through which these cell types respond to dopamine, in order to address the impact this has on neurodegenerative and psychiatric pathologies such as Parkinson's disease. A fur-ther aim is to illustrate the gaps in our understanding of the physiological roles of dopamine to encourage more targeted research focused on understanding the consequences of aberrant dopamine production on immune regulation. These highlights may prompt scientists in the field to consider alternative functions of this important neurotransmitter when targeting neuroinflammatory/neurodegenerative pathologies.
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论文发表日期：2020-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 2173-2185 )
英文信息