Mounting evidence of FKBP12 implication in neurodegeneration
Gabriella Caminati1
Piero Procacci2
1.Department of Chemistry "Ugo Schiff",University of Florence,Sesto Fiorentino,Italy;Center for Colloid and Surface Science(CSGI),University of Florence,Sesto Fiorentino,Italy2.Department of Chemistry "Ugo Schiff",University of Florence,Sesto Fiorentino,Italy
摘要：Intrinsically disordered proteins, such as tau or α-synuclein, have long been associated with a dysfunc-tional role in neurodegenerative diseases. In Alzheimer's and Parkinson's' diseases, these proteins, sharing a common chemical-physical pattern with alternating hydrophobic and hydrophilic domains rich in pro-lines, abnormally aggregate in tangles in the brain leading to progressive loss of neurons. In this review, we present an overview linking the studies on the implication of the peptidyl-prolyl isomerase domain of immunophilins, and notably FKBP12, to a variety of neurodegenerative diseases, focusing on the mo-lecular origin of such a role. The involvement of FKBP12 dysregulation in the aberrant aggregation of disordered proteins pinpoints this protein as a possible therapeutic target and, at the same time, as a pre-dictive biomarker for early diagnosis in neurodegeneration, calling for the development of reliable, fast and cost-effective detection methods in body fluids for community-based screening campaigns.
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论文发表日期：2020-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 2195-2202 )
英文信息