Targeting cannabidiol to specific areas of the brain: an ultrasound-based strategy
Jacopo Junio Valerio Branca
Donatello Carrino
Alessandra Pacini
1.Department of Experimental and Clinical Medicine,University of Firenze,Florence,Italy2.Department of Experimental and Clinical Medicine,University of Firenze,Florence,Italy3.Department of Experimental and Clinical Medicine,University of Firenze,Florence,Italy
摘要：Brain diseases, ranging from central nervous system (CNS) dis-orders to brain cancers, are some of the most prevalent pathol-ogies in the world. Despite the high incidence, many of these diseases lack successful treatments because of inadequate drug development in comparison to other therapeutic areas. In par-ticular, even if many drugs have shown the potential to tackle some neurological disorders including Alzheimer's and Parkin-son's diseases and many other associated CNS pathologies, their delivery in specific brain areas and in adequate concentrations represent the real obstacle to the treatment of these pathologies. The reason for this is twofold. First, the presence of the blood-brain barrier (BBB) ensures that the brain is separated by the systemic circulation. Indeed, the BBB is a well-known complex anatomical structural barrier that plays a pivotal role in protect-ing the parenchyma of the CNS from potential toxicants and dangerous elements that could be present in the blood circula-tion (Branca et al., 2019b). For this reason, the BBB is the main obstacle that prevents most systematically administered drugs from entering the CNS. In these instances, the link of lipid groups to the polar ends of the therapeutic molecules were used to enhance drug delivery across the BBB. Similarly, ligands, in-volved in the specific interactions with endothelial transporters, were often incorporated into the therapeutic agents for the ini-tiation of receptor-mediated transcytosis at BBB endothelium. Despite these strategies, many studies have reported that less than 1％ of total injected dose reaches the brain by intravenous administration because the BBB hinders about 95％ of drug de-livery (Dong, 2018).
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论文发表日期：2020-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2247-2248 )