Cognitive impairment in multiple sclerosis: lessons from cerebrospinal fluid biomarkers
Lorenzo Gaetani
Nicola Salvadori
Elena Chipi
Lucia Gentili
Angela Borrelli
Lucilla Parnetti
Massimiliano Di Filippo
1.Section of Neurology,Department of Medicine,University of Perugia,Perugia,Italy2.Section of Neurology,Department of Medicine,University of Perugia,Perugia,Italy3.Section of Neurology,Department of Medicine,University of Perugia,Perugia,Italy4.Section of Neurology,Department of Medicine,University of Perugia,Perugia,Italy5.Section of Neurology,Department of Medicine,University of Perugia,Perugia,Italy6.Section of Neurology,Department of Medicine,University of Perugia,Perugia,Italy7.Section of Neurology,Department of Medicine,University of Perugia,Perugia,Italy
摘要：Cognitive impairment is a common clinical manifestation of multiple sclerosis, but its pathophysiology is not completely understood. White and grey matter injury together with synaptic dysfunction do play a role. The measurement of biomarkers in the cerebrospinal fluid and the study of their association with cognitive impairment may provide interesting in vivo evidence of the biological mechanisms underlying multiple sclerosis-related cognitive impairment. So far, only a few studies on this topic have been published, giving interesting results that deserve further investigation. Cerebrospinal fluid biomarkers of different pathophysiological mechanisms seem to reflect different neuropsychological patterns of cognitive deficits in multiple sclerosis. The aim of this review is to discuss the studies that have correlated cerebrospinal fluid markers of immune, glial and neuronal pathology with cognitive impairment in multiple sclerosis. Although preliminary, these findings suggest that cerebrospinal fluid biomarkers show some correlation with cognitive performance in multiple sclerosis, thus providing interesting insights into the mechanisms underlying the involvement of specific cognitive domains.
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论文发表日期：2021-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 36-42 )
英文信息