Application of modern neuroimaging technology in the diagnosis and study of Alzheimer's disease
Hong-Mei Zeng1
Hua-Bo Han2
Qi-Fang Zhang3
Hua Bai4
1.Department of Neurology,Third Affiliated Hospital of Guizhou Medical University,Duyun,Guizhou Province,China;Department of Neurology,Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou Province,China2.Department of Radiology,Third Affiliated Hospital of Guizhou Medical University,Duyun,Guizhou Province,China3.Key Laboratory of Endemic and Ethnic Diseases of Ministry of Education,and Key Laboratory of Medical Molecular Biology,Guizhou Medical University,Guiyang,Guizhou Province,China4.Department of Neurology,Third Affiliated Hospital of Guizhou Medical University,Duyun,Guizhou Province,China;Department of Neurology,Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou Province,China;Medical Experiment Center,Third Affiliated Hospital of Guizhou Medical University,Duyun,Guizhou Province,China
摘要：Neurological abnormalities identified via neuroimaging are common in patients with Alzheimer's disease. However, it is not yet possible to easily detect these abnormalities using head computed tomography in the early stages of the disease. In this review, we evaluated the ways in which modern imaging techniques such as positron emission computed tomography, single photon emission tomography, magnetic resonance spectrum imaging, structural magnetic resonance imaging, magnetic resonance diffusion tensor imaging, magnetic resonance perfusion weighted imaging, magnetic resonance sensitive weighted imaging, and functional magnetic resonance imaging have revealed specific changes not only in brain structure, but also in brain function in Alzheimer's disease patients. The reviewed literature indicated that decreased fluorodeoxyglucose metabolism in the temporal and parietal lobes of Alzheimer's disease patients is frequently observed via positron emission computed tomography. Furthermore, patients with Alzheimer's disease often show a decreased N-acetylaspartic acid/creatine ratio and an increased myoinositol/creatine ratio revealed via magnetic resonance imaging. Atrophy of the entorhinal cortex, hippocampus, and posterior cingulate gyrus can be detected early using structural magnetic resonance imaging. Magnetic resonance sensitive weighted imaging can show small bleeds and abnormal iron metabolism. Task-related functional magnetic resonance imaging can display brain function activity through cerebral blood oxygenation. Resting functional magnetic resonance imaging can display the functional connection between brain neural networks. These are helpful for the differential diagnosis and experimental study of Alzheimer's disease, and are valuable for exploring the pathogenesis of Alzheimer's disease.
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论文发表日期：2021-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 73-79 )
英文信息