Neuroregeneration and functional recovery after stroke:advancing neural stem cell therapy toward clinical application
Yang Jiao1
Yu-Wan Liu2
Wei-Gong Chen1
Jing Liu1
1.Stem Cell Clinical Research Center,National Joint Engineering Laboratory,Regenerative Medicine Center,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning Province,China;Dalian Innovation Institute of Stem Cells and Precision Medicine,Dalian,Liaoning Province,China2.Stem Cell Clinical Research Center,National Joint Engineering Laboratory,Regenerative Medicine Center,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning Province,China
摘要：Stroke is a main cause of death and disability worldwide. The ability of the brain to self-repair in the acute and chronic phases after stroke is minimal; however, promising stem cell-based interventions are emerging that may give substantial and possibly complete recovery of brain function after stroke. Many animal models and clinical trials have demonstrated that neural stem cells (NSCs) in the central nervous system can orchestrate neurological repair through nerve regeneration, neuron polarization, axon pruning, neurite outgrowth, repair of myelin, and remodeling of the microenvironment and brain networks. Compared with other types of stem cells, NSCs have unique advantages in cell replacement, paracrine action, inflammatory regulation and neuroprotection. Our review summarizes NSC origins, characteristics, therapeutic mechanisms and repair processes, then highlights current research findings and clinical evidence for NSC therapy. These results may be helpful to inform the direction of future stroke research and to guide clinical decision-making.
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论文发表日期：2021-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 80-92 )
英文信息