A novel role for tissue-nonspecific alkaline phosphatase at the blood-brain barrier during sepsis
Divine C.Nwafor1
Candice M.Brown2
1.Department of Neuroscience,West Virginia University Health Science Center,Morgantown,WV,USA2.Department of Neuroscience,West Virginia University Health Science Center,Morgantown,WV,USA;Department of Microbiology,Immunology,and Cell Biology,School of Medicine,West Virginia University Health Science Center,Morgantown,WV,USA
摘要：Sepsis and the blood-brain barrier (BBB):
Sepsis is a life threatening systemic inflammatory condition involving multi-organ dysfunction. The World Health Organization estimates that about 30 million people are affected by sepsis every year, and at least 6 million people die from sepsis each year. Out of approximately 24 million sepsis survivors, it is estimated that 70% of these individuals will experience some form of long-term neurological impairment (Iwashyna et al., 2010). Thus, when combined with prevention, diagnosis, and therapeutic management strategies, a functional understanding of the mechanisms that promote sepsis-associated neurological impairment is necessary to address the clinical challenges and economic burdens faced when treating sepsis.
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论文发表日期：2021-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 99-100 )