Membrane progesterone receptors (mPRs/PAQRs) in Schwann cells represent a promising target for the promotion of neuroregeneration
Luca F. Castelnovo1
Peter Thomas1
Valerio Magnaghi2
1.Marine Science Institute, University of Texas at Austin, Port Aransas, TX, USA2.Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan,Italy
摘要：Schwann cells and neuroregeneration: Peripheral nerve injury is a common cause of morbidity, which affects millions of people worldwide. The peripheral nervous system, differently from the central nervous system, has an intrinsic ability to regenerate after injury. However, in most cases the regenerative outcome is not completely satisfactory, in particular for long-gap peripheral nerve injuries in which the microsurgical approach is not possible. In these cases, the current research effort is mostly aimed at the identification of pharmacological and/or cell therapy approaches that, coupled with the use of biomaterial conduits, provide scaffold, mechanical support and guidance to the regeneration process, and can increase regeneration speed and efficiency (Faroni et al., 2015).
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论文发表日期：2021-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 281-282 )