Stem cell heterogeneity and regenerative competence: the enormous potential of rare cells
Emily A.B. Gilbert1
Cindi M. Morshead2
1.Terrence Donnelly Centre for Cellular and Biomolecular Research;Division of Anatomy, Department of Surgery, University of Toronto, Toronto, ON, Canada2.Terrence Donnelly Centre for Cellular and Biomolecular Research;Division of Anatomy, Department of Surgery, University of Toronto, Toronto, ON, Canada;Institute of Biomedical and Biochemical Engineering, Institute of Medical Science, University of Toronto; KITE, Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada
摘要：Reconstitution of complex multi-tissue organs is one of the most impressive feats of biology and is observed across regeneration-competent vertebrate species, including teleost fish (e.g., zebrafish), urodeles (e.g., axolotls and newts), and some lizards. Regenerative ability within these species ranges from muscle (including cardiac), skeletal structures, to complex systems such as the brain, spinal cord and parts of the eye which are all capable of structural and functional repair following injury (Tanaka and Ferretti, 2009). In stark contrast, re-establishment of multi-tissue structures is very rarely observed following embryogenesis in regeneration-incompetent mammals. Regrowth of digit tips is the most dramatic example of mammalian regeneration, but pales in comparison to other species in the animal kingdom. Undoubtedly, a complete recapitulation of complex organs or structures in mammals will remain out of reach for a considerable time; however, an improved understanding of regenerative mechanisms would likely enhance the development of novel regenerative medicine strategies. Here we focus on the diversity and commonalities of stem cells, which could underlie complex tissue regeneration.
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论文发表日期：2021-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 285-286 )