Chemical biology: a toolbox to unlock neurochemical epigenetics?
Dennis ?zcelik
Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark;Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada
摘要：The complex challenges of studying neurochemistry: Neurochemistry comprises the molecular and biochemical roles of a vast variety of chemical compounds, including amino acids, peptides, gaseous molecules, and small molecules such as monoamines, which are crucial for the physiology of neurons, synapses and neural networks. Prominent neurochemical agents of the nervous system are the monoamines dopamine and serotonin. They are commonly associated with well-being and happiness but this perception is misleading since both molecules execute very complex and diverse physiological functions in the nervous system and in other tissues (Berger at al., 2009; Meiser et al., 2013). The specific function of dopamine and serotonin is very difficult to isolate, extrapolate and understand because they are widespread in the organism and involved in a multitude of biological processes. In addition, their chemical properties hinder scientific interrogation. For example, dopamine is very reactive, and quickly oxidizes in aqueous solution under physiological pH (Bisaglia et al., 2010). Dopamine oxidation products participate in a convoluted series of complex reaction cascades, which gives rise to a plethora of different metabolites, including large insoluble polymers. All these metabolites are capable of interacting with biological molecules, and inducing various biomolecular responses in the cell and in the tissue.
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论文发表日期：2021-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 298-299 )