Postnatal therapeutic approaches in genetic neurodevelopmental disorders
Gilad Levy1
Boaz Barak2
1.The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel2.The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel;The School of Psychological Sciences, Faculty of Social Sciences, Tel Aviv University, Tel Aviv, Israel
摘要：Genetic neurodevelopmental disorders are characterized by abnormal neurophysiological and behavioral phenotypes, affecting individuals worldwide. While the subject has been heavily researched, current treatment options relate mostly to alleviating symptoms,rather than targeting the altered genome itself. In this review, we address the neurogenetic basis of neurodevelopmental disorders, genetic tools that are enabling precision research of these disorders in animal models, and postnatal gene-therapy approaches for neurodevelopmental disorders derived from preclinical studies in the laboratory.
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论文发表日期：2021-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 414-422 )
英文信息