Connexin therapeutics: blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions
Monica L. Acosta1
Mohd N. Mat Nor2
Cindy X. Guo3
Odunayo O. Mugisho4
Frazer P. Coutinho5
Ilva D. Rupenthal4
Colin R. Green6
1.School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand;New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand;Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand;Brain Research New Zealand–Rangahau Roro Aotearoa, Auckland, New Zealand2.School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand;Faculty of Medicine, Universiti Sultan Zainal Abidin, Terengganu, Malaysia3.School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand4.Department of Ophthalmology, University of Auckland, Auckland, New Zealand;Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, Auckland, New Zealand;New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand5.Department of Ophthalmology, University of Auckland, Auckland, New Zealand6.Department of Ophthalmology, University of Auckland, Auckland, New Zealand;New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand
摘要：Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of diseases. Some of these compounds are now in clinical trials, but for many of them, the literature is inconclusive about themolecular effect on the tissue, despite evidence of functional recovery. Blocking the different channel types has distinct physiological and pathological implications and this review describes current knowledge of connexin and pannexin protein channels, their function as channels and possible mechanisms of the channel block effect for the latest therapeutic compounds. We summarize the evidence implicating pannexins and connexins in disease, considering their homeostatic versus pathological roles, their contribution to excesive ATP release linked to disease onset and progression.
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论文发表日期：2021-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 482-488 )
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