Efficacy of epothilones in central nervous system trauma treatment: what has age got to do with it?
Jayden Clark
Zhendan Zhu
Jyoti Chuckowree
Tracey Dickson
Catherine Blizzard
1.Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia2.Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia3.Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia4.Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia5.Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
摘要：Central nervous system injury, specifically traumatic brain and spinal cord injury, can have significant long lasting effects. There are no comprehensive treatments to combat theinjury and sequalae of events that occurring following a central nervous system trauma. Herein we discuss the potential for the epothilone family of microtubule stabilizing agents to improve outcomes following experimentally induced trauma. These drugs, which are able to cross the blood-brain barrier, may hold great promise for the treatment of central nervous system trauma and the current literature presents the extensive range of beneficial effects these drugs may have following trauma in animal models. Importantly, the effect of the epothilones can vary and our most recent contributions to this field indicate that the efficacy of epothilones following traumatic brain injury is dependent upon the age of the animals. Therefore, we present a case for a greater emphasis to be placed upon age when using an intervention aimed at neural regeneration and highlight the importance of tailoring the therapeutic regime in the clinic to the age of the patient to promote improved patient outcomes.
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论文发表日期：2021-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 618-620 )
英文信息