The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson's disease?
Vanessa Castelli1
Michele d'Angelo Massimiliano Quintiliani2
Elisabetta Benedetti1
Maria Grazia Cifone1
Annamaria Cimini3
1.Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy2.SIRE Srl, Naples, Italy3.Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy;Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, Temple University, Philadelphia, PA, USA
摘要：Neurodegenerative disease etiology is still unclear, but different contributing factors,such as lifestyle and genetic factors are involved. Altered components of the gut could play a key role in the gut-brain axis, which is a bidirectional system between the central nervous system and the enteric nervous system. Variations in the composition of the gut microbiota and its function between healthy people and patients have been reported for a variety of human disorders comprising metabolic, autoimmune, cancer, and, notably, neurodegenerative disorders. Diet can alter the microbiota composition, affecting the gut-brain axis function. Different nutraceutical interventions have been devoted to normalizing gut microbiome dysbiosis and to improving biological outcomes in neurological conditions, including the use of probiotics. Preclinical and clinical investigations discussed in this review strengthen the correlation between intestinal microbiota and brain and the concept that modifying the microbiome composition may improve brain neurochemistry, modulating different pathways. This review will discuss the potential use of probiotics for Parkinson's disease prevention or treatment or as adjuvant therapy, confirming that gut microbiota modulation influences different pro-survival pathways. Future investigations in Parkinson's disease should consider the role of the gut-brain axis and additional comprehension of the underlying mechanisms is extremely necessary.
机标关键词：
论文发表日期：2021-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 628-634 )
英文信息