Hippo signaling: bridging the gap between cancer and neurodegenerative disorders
Neha Gogia1
Anuradha Venkatakrishnan Chimata1
Prajakta Deshpande1
Aditi Singh2
Amit Singh3
1.Department of Biology, University of Dayton, Dayton, OH, USA2.Medical Candidate, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA3.Department of Biology, University of Dayton, Dayton, OH, USA;Premedical Program, University of Dayton, Dayton, OH, USA;Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH, USA;The Integrative Science and Engineering Center, University of Dayton, Dayton, OH, USA;Center for Genomic Advocacy (TCGA), Indiana State University, Terre Haute, IN, USA
摘要：During development, regulation of organ size requires a balance between cell proliferation, growth and cell death. Dysregulation of these fundamental processes can cause a variety of diseases. Excessive cell proliferation results in cancer whereas excessive cell deathresults in neurodegenerative disorders. Many signaling pathways known-to-date have a role in growth regulation. Among them, evolutionarily conserved Hippo signaling pathway is unique as it controls both cell proliferation and cell death by a variety of mechanisms during organ sculpture and development. Neurodegeneration, a complex process of progressive death of neuronal population, results in fatal disorders with no available cure to date. During normal development, cell death is required for sculpting of an organ. However, aberrant cell death in neuronal cell population can result in neurodegenerative disorders. Hippo pathway has gathered major attention for its role in growth regulation and cancer, however, other functions like its role in neurodegeneration are also emerging rapidly. This review highlights the role of Hippo signaling in cell death and neurodegenerative diseases and provide the information on the chemical inhibitors employed to block Hippo pathway. Understanding Hippo mediated cell death mechanisms will aid in development of reliable and effective therapeutic strategies in future.
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论文发表日期：2021-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 643-652 )
英文信息