Therapeutic potential of dental pulp stem cell transplantation in a rat model of Alzheimer 's disease
Xue-Mei Zhang1
Yuan-Jiao Ouyang1
Bing-Qian Yu2
Wei Li1
Mei-Yu Yu1
Jin-Yue Li1
Zhuo-Min Jiao1
Dan Yang1
Na Li3
Ying Shi1
Yun-Yun Xu1
Zhi-Jun He1
Duo Wang1
Hui Yue1
Jin Fu1
1.Department of Neurology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China2.Department of Neurology, Ningbo Hangzhou Bay Hospital, Ningbo, Zhejiang Province, China3.Department of Neurology, the First Hospital of Qiqihar, Qiqihar, Heilongjiang Province, China
摘要：Dental pulp stem cells are dental pulp-derived mesenchymal stem cells that originate from the neural crest. They exhibit greater potential for the treatment of nervous system diseases than other types of stem cells because of their neurogenic differentiation capability and their ability to secrete multiple neurotrophic factors. Few studies have reported Alzheimer's disease treatment using dental pulp stem cells. Rat models of Alzheimer's disease were established by injecting amyloid-β1–42 into the hippocampus. Fourteen days later, 5 × 106 dental pulp stem cells were injected into the hippocampus. Immunohistochemistry and western blot assays showed that dental pulp stem cell transplantation increased the expression of neuron-related doublecortin, NeuN, and neurofilament 200 in the hippocampus, while the expression of amyloid-β was decreased. Moreover, cognitive and behavioral abilities were improved. These findings indicate that dental pulp stem cell transplantation in rats can improve cognitive function by regulating the secretion of neuron-related proteins, which indicates a potential therapeutic effect for Alzheimer's disease. This study was approved by the Animal Ethics Committee of Harbin Medical University, China (approval No. KY2017-132) on February 21, 2017.
机标关键词：
分类号：R456(治疗学)R741(神经病学)Q2(细胞生物学)
论文发表日期：2021-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 893-898 )
英文信息