The Yin-Yang of osteopontin in nervous system diseases: damage versus repair
Giuseppe Cappellano
Domizia Vecchio
Luca Magistrelli
Nausicaa Clemente
Davide Raineri
Camilla Barbero Mazzucca
Eleonora Virgilio
Umberto Dianzani
Annalisa Chiocchetti
Cristoforo Comi
摘要：Osteopontin is a broadly expressed pleiotropic protein, and is attracting increased attention because of its role in the pathophysiology of several inflammatory, degenerative, autoimmune, and oncologic diseases. In fact, in the last decade, several studies have shown that osteopontin contributes to tissue damage not only by recruiting harmful inflammatory cells to the site of lesion, but also increasing their survival. The detrimental role of osteopontin has been indeed well documented in the context of different neurological conditions (i.e., multiple sclerosis, Parkinson's, and Alzheimer's diseases). Intriguingly, recent findings show that osteopontin is involved not only in promoting tissue damage (the Yin), but also in repair/regenerative mechanisms (the Yang), mostly triggered by the inflammatory response. These two apparently discordant roles are partly related to the presence of different functional domains in the osteopontin molecule, which are exposed after thrombin or metalloproteases cleavages. Such functional domains may in turn activate intracellular signaling pathways and mediate cell-cell and cell-matrix interactions. This review describes the current knowledge on the Yin and Yang features of osteopontin in nervous system diseases. Understanding the mechanisms behind the Yin/Yang would be relevant to develop highly specific tools targeting this multifunctional protein.
机标关键词：
资助基金：AGING and FOHN Projects,Fondazione Cariplo 2019-3277 and Associazione Ricerca sul Cancro(IG 20714)AGING and FOHN Projects,Fondazione Cariplo 2019-3277 and Associazione Ricerca sul Cancro(AIRC)AGING and FOHN Projects,Fondazione Cariplo 2019-3277 and Associazione Ricerca sul Cancro(Milano)
论文发表日期：2021-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1131-1137 )
英文信息