Dynamic glial response and crosstalk in demyelination- remyelination and neurodegeneration processes
Tianci Chu
Lisa B.E.Shields
Wenxin Zeng
Yi Ping Zhang
Yuanyi Wang
Gregory N.Barnes
Christopher B.Shields
Jun Cai
摘要：Multiple sclerosis is an autoimmune disease in which the immune system attacks the myelin sheath in the central nervous system. It is characterized by blood-brain barrier dysfunction throughout the course of multiple sclerosis, followed by the entry of immune cells and activation of local microglia and astrocytes. Glial cells (microglia, astrocytes, and oligodendrocyte lineage cells) are known as the important mediators of neuroinflammation, all of which play major roles in the pathogenesis of multiple sclerosis. Network communications between glial cells affect the activities of oligodendrocyte lineage cells and influence the demyelination-remyelination process. A finely balanced glial response may create a favorable lesion environment for efficient remyelination and neuroregeneration. This review focuses on glial response and neurodegeneration based on the findings from multiple sclerosis and major rodent demyelination models. In particular, glial interaction and molecular crosstalk are discussed to provide insights into the potential cell- and molecule-specific therapeutic targets to improve remyelination and neuroregeneration.
机标关键词：
资助基金：This work was partially supported by grants from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health(R21 NS098170)This work was partially supported by grants from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health(to JC and CBS)Kentucky Spinal Cord and Head Injury Research Trust(16-3A)Kentucky Spinal Cord and Head Injury Research Trust(to JC and CBS)and the National Natural Science Foundation of China(81601957)and the National Natural Science Foundation of China(to YW)
论文发表日期：2021-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 1359-1368 )
英文信息