Inflammation induces zebrafish regeneration
Maria Iribarne
Center for Zebrafish Research, Department of Biological Sciences;Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame,IN, USA
摘要：Tissue or organ regeneration is a complex process with successful outcomes depending on the type of tissue and organism.Upon damage,mammals can only efficiently restore a few tissues including the liver,skin,epithelia of the lung,kidney,and gut.In contrast,lower vertebrates such as zebrafish possess an extraordinary regeneration ability,which restores the normal function of a broad spectrum of tissues including heart,fin,brain,spinal cord,and retina.This regeneration process is either mediated by the proliferation of resident stem cells,or cells that dedifferentiate into a stem cell-like.In recent years,evidence has suggested that the innate immune system can modulate stem cell activity to initiate the regenerative response to damage.This review will explore some of the newer concepts of inflammation in zebrafish regeneration in different tissues.Understanding how inflammation regulates regeneration in zebrafish would provide important clues to improve the therapeutic strategies for repairing injured mammalian tissues that do not have an inherent regenerative capacity.
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论文发表日期：2021-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1693-1701 )
英文信息