Astrocytes:a double-edged sword in neurodegenerative diseases
Zhi-Bin Ding1
Li-Juan Song1
Qing Wang2
Gajendra Kumar3
Yu-Qing Yan4
Cun-Gen Ma4
1.The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Research Center of Neurobiology, Shanxi University of Chinese Medicine, Taiyuan, Shanxi Province, China;Department of Neurology, Affiliated Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China2.The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Research Center of Neurobiology, Shanxi University of Chinese Medicine, Taiyuan, Shanxi Province, China3.Department of Neuroscience, City University of Hong Kong, Tat Chee Avenue, Hong Kong Special Administrative Region, China4.The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Research Center of Neurobiology, Shanxi University of Chinese Medicine, Taiyuan, Shanxi Province, China;institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Medical School of Shanxi Datong Univ
摘要：Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the central nervous system by regulating homeostasis,increasing synaptic plasticity,and sustaining neuroprotective effects.Astrocytes become activated as a result of inflammatory responses during the progression of pathological changes associated with neurodegenerative disorders.Reactive astrocytes(neurotoxic A1 and neuroprotective A2)are triggered during disease progression and pathogenesis due to neuroinflammation and ischemia.However,only a limited body of literature describes morphological and functional changes of astrocytes during the progression of neurodegenerative diseases.The present review investigated the detrimental and beneficial roles of astrocytes in neurodegenerative diseases reported in recent studies,as these cells have promising therapeutic potential and offer new approaches for treatment of neurodegenerative diseases.
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论文发表日期：2021-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1702-1710 )
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