Topical delivery of nerve growth factor for treatment of ocular and brain disorders
Gemma Eftimiadi1
Marzia Soligo2
Luigi Manni2
Daniela Di Giuda3
Maria Lucia Calcagni3
Antonio Chiaretti1
1.Institute of Pediatrics, Fondazione Policlinico Universitario Agostino Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy2.institute of Translational Pharmacology, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy3.institute of Nuclear Medicine, Fondazione Policlinico Universitario Agostino Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy
摘要：Neurotrophins are a family of proteins that support neuronal proliferation,survival,and differentiation in the central and peripheral nervous systems,and are regulators of neuronal plasticity.Nerve growth factor is one of the best-described neurotrophins and has advanced to clinical trials for treatment of ocular and brain diseases due to its trophic and regenerative properties.Prior trials over the past few decades have produced conflicting results,which have principally been ascribed to adverse effects of systemic nerve growth factor administration,together with poor penetrance of the blood-brain barrier that impairs drug delivery.Contrastingly,recent studies have revealed that topical ocular and intranasal nerve growth factor administration are safe and effective,suggesting that topical nerve growth factor delivery is a potential alternative to both systemic and invasive intracerebral delivery.The therapeutic effects of local nerve growth factor delivery have been extensively investigated for different ophthalmic diseases,including neurotrophic keratitis,glaucoma,retinitis pigmentosa,and dry eye disease.Further,promising pharmacologic effects were reported in an optic glioma model,which indicated that topically administered nerve growth factor diffused far beyond where it was topically applied.These findings support the therapeutic potential of delivering topical nerve growth factor preparations intranasally for acquired and degenerative brain disorders.Preliminary clinical findings in both traumatic and non-traumatic acquired brain injuries are encouraging,especially in pediatric patients,and clinical trials are ongoing.The present review will focus on the therapeutic effects of both ocular and intranasal nerve growth factor delivery for diseases of the brain and eye.
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论文发表日期：2021-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 1740-1750 )
英文信息