New insights on the molecular mechanisms of collateral sprouting after peripheral nerve injury
Dominique Lemaitre1
Felipe A.Court2
1.Universidad del Desarrollo, Facultad de Medicina,Centro de Fisiología Celular e Integrativa, Santiago,Chile2.Center for Integrative Biology, Faculty of Sciences,Universidad Mayor, Santiago, Chile;Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile;The Buck Institute for Research on Aging, Novato,CA, USA
摘要：Axonal regeneration after injuries to the nervous system has been extensively studied due to its implication in motor and sensory functional recovery.Distinct types of regeneration has been identified,such as canonical axonal regeneration,defined as the growth of axons from the transected axonal stump to reinnervate the original target,or regenerative sprouting,in which the growth occurs from a region of the damaged axon either close or far from the injury site(Tuszynski and Steward,2012).Both types of axonal regeneration depend on cellular and molecular responses of the injured neuron.However,undamaged neurons can also react to an injury-induced environment by extending sprouts along their axons that functionally synapse with denervated targets,a process known as collateral sprouting(Collyer et al.,2014;Bao et al.,2016).
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论文发表日期：2021-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1760-1761 )