Synaptic mechanisms of cadmium neurotoxicity
Andrei N.Tsentsevitsky1
Alexey M.Petrov2
1.Laboratory of Biophysics of Synaptic Processes,Kazan Institute of Biochemistry and Biophysics,Federal Research Center "Kazan Scientific Center of RAS", 2/31 Lobachevsky Street, Box 30, Kazan,420111, Russia2.Laboratory of Biophysics of Synaptic Processes,Kazan Institute of Biochemistry and Biophysics,Federal Research Center "Kazan Scientific Center of RAS", 2/31 Lobachevsky Street, Box 30, Kazan,420111, Russia;Institute of Neuroscience, Kazan State Medial University, 49 Butlerova Street, Kazan, 420012,Russia
摘要：Cadmium(Cd)is a toxic heavy metal ubiquitously distributed in the environment(water,air,food,smoke)with extreme ability to accumulate in the human body due to its delayed clearance(half-life time 15-30 years).Consequently,prolonged exposure to low doses of Cd causes multi-organ toxicity.Remarkably,the central and peripheral nervous systems are considered as one of the most vulnerable targets.Excessive Cd exposure can profoundly aggravate common neurodegenerative diseases and peripheral polyneuropathies as well as lead to mental deficits in children(Branca et al.,2020).Conceivably,that Cd-induced defects in communication between neurons could be triggering events in Cd neurotoxicity.
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论文发表日期：2021-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1762-1763 )