Sex,ApoE4 and Alzheimer's disease:rethinking drug discovery in the era of precision medicine
Manish D.Paranjpe1
Jason K Wang1
Yun Zhou2
1.Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA,USA2.Mallinckrodt Institute of Radiology, Washington University in St.Louis School of Medicine, St.Louis, MO, USA
摘要：Alzheimer's disease(AD)is the most common cause of dementia and presents with an insidious onset and long prodromal period.Despite billions spent on clinical trials and decades of research,there are currently no disease modifying therapies approved for AD.Two of the most well-appreciated risk factors for AD include female sex and the presence of the apolipoprotein s4 allele(APOE4;Riedel et al,2016).In this Perspective,we highlight how greater disease subtyping through consideration of sex and APOE4 has the potential to elucidate new disease mechanisms,biomarkers and therapeutic strategies in AD(Figure 1).
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论文发表日期：2021-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1764-1765 )