Phenotypic heterogeneity in amyotrophic lateral sclerosis type 8 and modifying mechanisms of neurodegeneration
Danyllo Oliveira1
Sergio Verjovski-Almeida2
Mayana Zatz1
1.Human Genome and Stem Cell Research Center,Department of Genetics and Evolutionary Biology,Institute of Biosciences, University of S?o Paulo,S?o Paulo, SP, Brazil2.Laboratório de Express?o Gênica em Eucariotos,Instituto Butantan;Departmento de Bioquímica,Instituto de Química, Universidade de S?o Paulo,S?o Paulo, SP, Brazil
摘要：In his accounts"On longevity and shortness of life",Aristotle considered how diseased states could be interchangeably associated with long and short lifespans.He believed that the presence of opposite elements and the environment were the sole determinants of this variability.Nowadays,also struck by the same phenomenon observed by the Greek philosopher,human geneticists are still trying to define the etiological basis of the phenotypic plasticity in neurodegenerative disorders.Among such diseases,amyotrophic lateral sclerosis(ALS)stands out as a highly heterogeneous condition.
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论文发表日期：2021-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1776-1778 )