Protein post-translational modifications after spinal cord injury
Shuang Zhu1
Bing-Sheng Yang1
Si-Jing Li1
Ge Tong2
Jian-Ye Tan1
Guo-Feng Wu1
Lin Li1
Guo-Li Chen3
Qian Chen4
Li-Jun Lin1
1.Department of Joint and Orthopedics,Zhujiang Hospital,Southern Medical University,Guangzhou,Guangdong Province,China2.Department of Medical Ultrasonics,Guangdong Province Key Laboratory of Hepatology Research,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong Province,China3.Department of Orthopedics,Affiliated Hospital of Putian University,Putian,Fujian Province,China4.Cell and Molecular Biology Laboratory,Department of Orthopaedics,Alpert Medical School of Brown University/Rhode Island Hospital,Providence,RI,USA
摘要：Deficits in intrinsic neuronal capacities in the spinal cord, a lack of growth support, and suppression of axonal outgrowth by inhibitory molecules mean that spinal cord injury almost always has devastating consequences. As such, one of the primary targets for the treatment of spinal cord injury is to develop strategies to antagonize extrinsic or intrinsic axonal growth-inhibitory factors or enhance the factors that support axonal growth. Among these factors, a series of individual protein level disorders have been identified during the generation of axons following spinal cord injury. Moreover, an increasing number of studies have indicated that post-translational modifications of these proteins have important implications for axonal growth. Some researchers have discovered a variety of post-translational modifications after spinal cord injury, such as tyrosination, acetylation, and phosphorylation. In this review, we reviewed the post-translational modifications for axonal growth, functional recovery, and neuropathic pain after spinal cord injury, a better understanding of which may elucidate the dynamic change of spinal cord injury-related molecules and facilitate the development of a new therapeutic strategy for spinal cord injury.
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论文发表日期：2021-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1935-1943 )
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