Axonal mRNA localization and local translation in neurodegenerative diseases
Jin-Xin Lu1
Yang Wang2
Yi-Jie Zhang1
Mei-Fen Shen1
Hai-Ying Li1
Zheng-Quan Yu1
Gang Chen1
1.Department of Neurosurgery &Brain and Nerve Research Laboratory,The First Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province,China2.Department of Neurosurgery &Brain and Nerve Research Laboratory,The First Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province,China;Department of Neurosurgery,The First Affiliated Hospital of University of Science and Technology of China,Hefei,Anhui Province,China
摘要：The regulation of mRNA localization and local translation play vital roles in the maintenance of cellular structure and function. Many human neurodegenerative diseases, such as fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer's disease, and spinal muscular atrophy, have been characterized by pathological changes in neuronal axons, including abnormal mRNA translation, the loss of protein expression, or abnormal axon transport. Moreover, the same protein and mRNA molecules have been associated with variable functions in different diseases due to differences in their interaction networks. In this review, we briefly examine fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer's disease, and spinal muscular atrophy, with a focus on disease pathogenesis with regard to local mRNA translation and axon transport, suggesting possible treatment directions.
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论文发表日期：2021-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1950-1957 )
英文信息