Sleep disorders in Alzheimer's disease: the predictive roles and potential mechanisms
Huang Kuang1
Yu-Ge Zhu1
Zhi-Feng Zhou1
Mei-Wen Yang2
Fen-Fang Hong3
Shu-Long Yang1
1.Department of Physiology,College of Medicine,Nanchang University,Nanchang,Jiangxi Province,China2.Department of Nurse,Nanchang University Hospital,Nanchang,Jiangxi Province,China3.Department of Experimental Teaching Center,Nanchang University,Nanchang,Jiangxi Province,China
摘要：Sleep disorders are common in patients with Alzheimer's disease, and can even occur in patients with amnestic mild cognitive impairment, which appears before Alzheimer's disease. Sleep disorders further impair cognitive function and accelerate the accumulation of amyloid-β and tau in patients with Alzheimer's disease. At present, sleep disorders are considered as a risk factor for, and may be a predictor of, Alzheimer's disease development. Given that sleep disorders are encountered in other types of dementia and psychiatric conditions, sleep-related biomarkers to predict Alzheimer's disease need to have high specificity and sensitivity. Here, we summarize the major Alzheimer's disease-specific sleep changes, including abnormal non-rapid eye movement sleep, sleep fragmentation, and sleep-disordered breathing, and describe their ability to predict the onset of Alzheimer's disease at its earliest stages. Understanding the mechanisms underlying these sleep changes is also crucial if we are to clarify the role of sleep in Alzheimer's disease. This paper therefore explores some potential mechanisms that may contribute to sleep disorders, including dysregulation of the orexinergic, glutamatergic, and γ-aminobutyric acid systems and the circadian rhythm, together with amyloid-β accumulation. This review could provide a theoretical basis for the development of drugs to treat Alzheimer's disease based on sleep disorders in future work.
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论文发表日期：2021-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1965-1972 )
英文信息