Current application of neurofilaments in amyotrophic lateral sclerosis and future perspectives
Yuri Matteo Falzone1
Tommaso Russo1
Teuta Domi2
Laura Pozzi2
Angelo Quattrini2
Massimo Filippi3
Nilo Riva1
1.Neuropathology Unit,Institute of Experimental Neurology,Division of Neuroscience,San Raffaele Scientific Institute,Milan,Italy;Neurology and Neurorehabilitation Unit,IRCCS SanRaffaele Scientific Institute,Milan,Italy2.Neuropathology Unit,Institute of Experimental Neurology,Division of Neuroscience,San Raffaele Scientific Institute,Milan,Italy3.Neurology and Neurorehabilitation Unit,IRCCS SanRaffaele Scientific Institute,Milan,Italy;Neurophysiology Unit,IRCCS San Raffaele Scientific Institute,Milan,Italy;Neuroimaging Research Unit,Institute of Experimental Neurology,Division of Neuroscience,IRCCS San Raffaele Scientific Institute,Milan,Italy;Vita-Salute San Rafaele University,Milan,Italy
摘要：Motor neuron disease includes a heterogeneous group of relentless progressive neurological disorders defined and characterized by the degeneration of motor neurons. Amyotrophic lateral sclerosis is the most common and aggressive form of motor neuron disease with no effective treatment so far. Unfortunately, diagnostic and prognostic biomarkers are lacking in clinical practice. Neurofilaments are fundamental structural components of the axons and neurofilament light chain and phosphorylated neurofilament heavy chain can be measured in both cerebrospinal fluid and serum. Neurofilament light chain and phosphorylated neurofilament heavy chain levels are elevated in amyotrophic lateral sclerosis, reflecting the extensive damage of motor neurons and axons. Hence, neurofilaments are now increasingly recognized as the most promising candidate biomarker in amyotrophic lateral sclerosis. The potential usefulness of neurofilaments regards various aspects, including diagnosis, prognosis, patient stratification in clinical trials and evaluation of treatment response. In this review paper, we review the body of literature about neurofilaments measurement in amyotrophic lateral sclerosis. We also discuss the open issues concerning the use of neurofilaments clinical practice, as no overall guideline exists to date;finally, we address the most recent evidence and future perspectives.
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论文发表日期：2021-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1985-1991 )
英文信息