OTX2 signaling in retinal dysfunction, degeneration and regeneration
Kenneth.L.Moya1
Raoul Torero Ibad2
1.Centre for Interdisciplinary Research in Biology(CIRB),Collège de France,CNRS UMR 7241,INSERM U1050,Labex MemoLife,PSL Research University,Paris,France2.Centre for Interdisciplinary Research in Biology(CIRB),Collège de France,CNRS UMR 7241,INSERM U1050,Labex MemoLife,PSL Research University,Paris,France;Univ. Lille,CNRS,UMR 8523 -PhLAM -Physique des Lasers Atomes et Molécules,F-59000 Lille,France
摘要：The protein OTX2 in the retina is necessary for the maintenance of normal physiologic processes, and may be a promising therapeutic agent for some ophthalmic diseases. In this Perspective, we first shortly introduce the organization of the retina and the importance of OTX2 expression. We then present an example of reduced OTX2 activity in the developed retina associated with structural and functional consequences. We next show that homeoproteins can have neuroprotective functions. We finally review several clear examples of OTX2 non-cell autonomous activity in the retina and the effects of diminishing or providing extracellular OTX2.
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论文发表日期：2021-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2002-2003 )