Neuroglobin and neuroprotection: the role of natural and synthetic compounds in neuroglobin pharmacological induction
Lidia Ciccone1
Susanna Nencetti1
Simone Socci2
Elisabetta Orlandini3
1.Department of Pharmacy, University of Pisa, Pisa, Italy2.Department of Earth Sciences, University of Pisa, Pisa, Italy3.Department of Earth Sciences, University of Pisa, Pisa, Italy;Research Center "E. Piaggio," University of Pisa, Pisa, Italy
摘要：Neuroglobin (Ngb) is a 17 kDa monomeric hexa-coordinated heme protein belonging to the globin family. Ngb is mainly expressed in neurons of the central and peripheral nervous system, although moderate levels of Ngb have been detected in non-nervous tissues. In the past decade, Ngb has been studied for its neuroprotective role in a large number of neurological disorders such as Alzheimer's disease, Huntington's disease, brain ischemia and hypoxia. This review discusses and summarizes the natural compounds and the small synthetic molecules capable of modulating Ngb expression that exhibits a protective role against various neurodegenerative diseases.
机标关键词：
论文发表日期：2021-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 2353-2358 )
英文信息