Neurovascular ageing: transcriptomic readout and implications on therapeutic targeting in Alzheimer's disease
Zhongqi Li1
Bonaventure Ip2
Vincent C.T.Mok3
Ho Ko4
1.Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China2.Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China3.Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;Margaret K. L. Cheung Research Centre for Management of Parkinsonism, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;Chow Yuk Ho Technology Centre for Innovative Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China4.Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;Margaret K. L. Cheung Research Centre for Management of Parkinsonism, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;Chow Yuk Ho Technology Centre for Innovative Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China;Gerald Choa Neuroscience Centre, School of Biomedical Sciences, Department of Psychiatry, Peter Hung Pain Research Institute, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
摘要：Ageing is one of the greatest risk factors for neurodegenerative diseases. How the complex biological changes in ageing increase the brain's susceptibility to neurodegeneration remains incompletely understood. Research into neurodegenerative disorders has shifted from a neuron-centric approach, to the contributing roles of age-related neurovascular and glial cell dysfunction.
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论文发表日期：2021-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2411-2412 )