Rogue gene networks gone awry in Alzheimer's disease
Emily Miyoshi
Vivek Swarup
Department of Neurobiology and Behavior, University of California, Irvine, CA, USA;Institute for Memory Impairments and Neurological Disorders (MIND), University of California, Irvine, CA, USA
摘要：The human brain consists of billions of cells encompassing hundreds of distinct cell-types, each with unique functions and properties. Identification of the molecular architecture of the brain has been revolutionized by next-generation sequencing (NGS), as evident by recent transcriptomic and genetic/epigenetic studies. NGS paved the way to perform large-scale, genome-wide sequencing studies on human postmortem brain tissue, and this offered an unprecedented opportunity to elucidate the genetic bases of polygenic neurological disorders, like Alzheimer's disease (AD).
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论文发表日期：2021-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2415-2416 )