Research advances on how metformin improves memory impairment in "chemobrain"
Ahmad Alhowail1
Sridevi Chigurupati2
1.Department of Pharmacology and Toxicology,College of Pharmacy,Qassim University,Buraidah,Kingdom of Saudi Arabia2.Department of Medicinal Chemistry and Pharmacognosy,College of Pharmacy,Qassim University,Buraydah,Kingdom of Saudi Arabia
摘要：Cognitive impairment caused by chemotherapy, referred to as "chemobrain," is observed in approximately 70％ of cancer survivors. However, it is not completely understood how chemotherapy induces cognitive dysfunction, and clinical treatment strategies for this problem are lacking. Metformin, used as a first-line treatment for type 2 diabetes mellitus, is reported to reduce the effects of chemobrain. Recently, several studies have examined the effect of metformin in rescuing chemobrain. This review discusses recent clinical/preclinical studies that addressed some mechanisms of chemobrain and evaluates the effect of metformin in rescuing chemobrain and its potential mechanisms of action.
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论文发表日期：2022-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 15-19 )
英文信息