Optogenetic activation of intracellular signaling based on light-inducible protein-protein homo-interactions
Peiyuan Huang1
Zhihao Zhao1
Liting Duan2
1.Department of Biomedical Engineering,The Chinese University of Hong Kong,Sha Tin,Hong Kong Special Administrative Region,China2.Department of Biomedical Engineering,The Chinese University of Hong Kong,Sha Tin,Hong Kong Special Administrative Region,China;Shun Hing Institute of Advanced Engineering(SHIAE),The Chinese University of Hong Kong,Sha Tin,Hong Kong Special Administrative Region,China
摘要：Dynamic protein-protein interactions are essential for proper cell functioning. Homo-interaction events—physical interactions between the same type of proteins—represent a pivotal subset of protein-protein interactions that are widely exploited in activating intracellular signaling pathways. Capacities of modulating protein-protein interactions with spatial and temporal resolution are greatly desired to decipher the dynamic nature of signal transduction mechanisms. The emerging optogenetic technology, based on genetically encoded light-sensitive proteins, provides promising opportunities to dissect the highly complex signaling networks with unmatched specificity and spatiotemporal precision. Here we review recent achievements in the development of optogenetic tools enabling light-inducible protein-protein homo-interactions and their applications in optical activation of signaling pathways.
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论文发表日期：2022-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 25-30 )
英文信息