The gut microbiome: implications for neurogenesis and neurological diseases
Cheng Liu
Shang-Yu Yang
Long Wang
Fang Zhou
1.Department of Healthcare Administration,College of Medical and Health Science,Asia University,Taichung,Taiwan,China2.Department of Anesthesiology,Renmin Hospital of Wuhan University,Wuhan,Hubei Province,China
摘要：There is an increasing recognition of the strong links between the gut microbiome and the brain, and there is persuasive evidence that the gut microbiome plays a role in a variety of physiological processes in the central nervous system. This review summarizes findings that gut microbial composition alterations are linked to hippocampal neurogenesis, as well as the possible mechanisms of action; the existing literature suggests that microbiota influence neurogenic processes, which can result in neurological disorders. We consider this evidence from the perspectives of neuroinflammation, microbial-derived metabolites, neurotrophins, and neurotransmitters. Based on the existing research, we propose that the administration of probiotics can normalize the gut microbiome. This could therefore also represent a promising treatment strategy to counteract neurological impairment.
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论文发表日期：2022-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 53-58 )
英文信息