Celeboxib-mediated neuroprotection in focal cerebral ischemia: an interplay between unfolded protein response and inflammation
María Santos-Galdiano1
Diego Pérez-Rodríguez2
Arsenio Fernández-López3
1.área de Biología Celular,Instituto de Biomedicina,Campus de Vegazana s/n,Universidad de León,León,Spain2.área de Biología Celular,Instituto de Biomedicina,Campus de Vegazana s/n,Universidad de León,León,Spain;Department of Clinical and Movement Neurosciences,UCL Queen Square Institute of Neurology,London,UK3.área de Biología Celular,Instituto de Biomedicina,Campus de Vegazana s/n,Universidad de León,León,Spain;Neural Therapies SL,Campus de Vegazana s/n,León,Spain
摘要：Ischemic stroke results from the temporary or permanent lack of blood supply in the brain due to the occlusion of a brain blood vessel. Around 85％ of patients with cerebrovascular accidents suffer from ischemic strokes. Although cerebrovascular accidents represent the major cause of death and permanent disability worldwide, thus far, only processes addressed at eliminating the vessel obstruction (chemical or mechanical) have been successfully developed. Many neuroprotective strategies have been tested in preclinical studies, but clinical trials have, so far, failed to result in beneficial effects. These issues may be due to the very complex pathophysiology of ischemic stroke, which involves the integration of multiple signaling pathways ultimately resulting in neuronal loss.
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论文发表日期：2022-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 302-303 )