Neuron-specific enolase in cerebrospinal fluid as a biomarker of brain damage in infants with hypoxic-ischemic encephalopathy
Alfredo Garcia-Alix1
Juan Arnaez2
1.Neonatal Neurology,NeNe Foundation,Spain2.Neonatal Neurology,NeNe Foundation,Spain,Neonatology,Complejo Universitario de Burgos,Burgos,Spain
摘要：Neonatal encephalopathy resulting from an asphyxial episode occurring perinatally is a major cause of death and of permanent neurological disabilities worldwide. Therapeutic hypothermia (TH) started within 6 hours of life and maintained for 72 hours is now well established as standard treatment for infants with moderate-to-severe hypoxic-ischemic encephalopathy (HIE). Those infants have altered consciousness and other signs of neurological dysfunction. However, nearly half of infants with moderate-to-severe HIE treated with TH still die or survive with disability despite treatment. In addition, the globalization of TH is still pending, especially in low-to-middle income countries where prevalence rates of HIE are particularly high.
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论文发表日期：2022-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 318-319 )