Emerging roles of NRBF2/PI3KC3 axis in maintaining homeostasis of brain and guts
Ming-Yue Wu
Cui-Zan Cai
Chuanbin Yang
Zhenyu Yue
Ye Chen
ZhaoXiang Bian
Min Li
Jia-Hong Lu
1.State Key Laboratory of Quality Research inChinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao Special Administrative Region,China2.School of Chinese Medicine,Hong Kong Baptist University,Hong Kong Special Administrative Region,China3.Department of Neurology and Neuroscience,Friedman Brain Institute,Icahn School of Medicine at Mount Sinai,New York,NY,USA4.Department of Gastroenterology,State Key Laboratory of Organ Failure Research,Guangdong Provincial Key Laboratory of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong Province,China
摘要：NRBF2 has been identified as the fifth component of PI3KC3 complex and is required for maintaining the kinase activity to promote autophagy. However, the physiological and pathological roles of NRBF2 are largely unknown. In our recent studies, we have revealed that NRBF2 plays an important role in preventing the Alzheimer's disease (AD) and inflammatory bowel disease (IBD) development, via the mechanisms involving regulating autophagosome maturation and phagosome maturation. The findings expand our understanding towards the physiological role of PI3KC3 complex and provide a potential strategy for AD and IBD treatment by regulating PI3KC3 complex activity.
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论文发表日期：2022-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 323-324 )