The role of miRNA in retinal ganglion cell health and disease
Ben Mead1
Stanislav Tomarev2
1.School of Optometry and Vision Sciences,Cardiff University,Cardiff,UK2.Section of Retinal Ganglion Cell Biology,Laboratory of Retinal Cell and Molecular Biology,National Eye Institute,National Institutes of Health,Bethesda,MD,USA
摘要：miRNA are short non-coding RNA responsible for the knockdown of proteins through their targeting and silencing of complimentary mRNA sequences. The miRNA landscape of a cell thus affects the levels of its proteins and has significant consequences to its health. Deviations in this miRNA landscape have been implicated in a variety of neurodegenerative diseases and have also garnered interest as targets for treatment. Retinal ganglion cells are the sole projection neuron of the retina with their axons making up the optic nerve. They are a focus of study not only for their importance in vision and the myriad of blinding diseases characterized by their dysfunction and loss, but also as a model of other central nervous system diseases such as spinal cord injury and traumatic brain injury. This review summarizes current knowledge on the role of miRNA in retinal ganglion cell function, highlighting how perturbations can result in disease, and how modulating their abundance may provide a novel avenue of therapeutic research.
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论文发表日期：2022-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 516-522 )
英文信息