Heat shock factor 1 is a direct anti-amyloid factor: connecting neurodegeneration and uncontrolled growth
Zijian Tang
Chengkai Dai
Mouse Cancer Genetics Program,Center forCancer Research,National Cancer Institute,Frederick,MD,USA
摘要：Worldwide, more than 40 million people are afflicted with Alzheimer's disease (AD) (Esquerda-Canals et al., 2017). AD is a devastating neurodegenerative disroder characterized by progressive decline in cognitive abilities. A hallmark of AD and other neurodegenerative disorders in humans is the aggregation of proteins into amyloid fibrils and their deposition into plaques and intracellular inclusions (Iadanza et al., 2018). In AD, following a series of proteolytic cleavage events amyloid precursor proteins give rise to Aβ monomers, which, in turn, assemble into soluble amyloid oligomers (AOs) that ultimately become insoluble mature amyloid fibrils enriched with highly ordered cross β-sheet structures. This entire process is termed as amyloidogenesis (Chen et al., 2017).
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论文发表日期：2022-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 559-560 )